29th November 2018.

This month:

  • Aptamer Group data on selective bind and elution reusability of aptamer  purification columns
  • Small molecule analysis webinar with Pall ForteBio BLI platform
  • Our CEO Today United Kingdom award
  • Interesting applications in antibiotic biosensors and ELISA antibody/aptamer pairs

Novel Solutions – Purification 

Reproducibility of aptamers that bind and release under defined conditions

  • Less expensive
  • Gentle tailored elution
  • No tags required

 

The immobilised aptamer captures the target protein in a complex culture harvest and then releases it in target specific elution buffer.  Using Biolayer Interferometry (BLI) the regenerated surface shows repeated use of over 50+ cycles demonstrating the reproducibility of aptamers for this target and application.

Webinar Rebroadcast

Flexible Monitoring of Small Molecules in Complex Matrices with Aptamer Affinity Reagents using Bio-Layer Interferometry

December 5th, 2018 – 8am PST

The Aptamer Group is pleased to work with Pall ForteBio on this informative webinar.  Aptamer Group uses Bio-Layer Interferometry (BLI) to screen and characterize the interactions of aptamers with their respective targets. The Octet® and BLItz® platforms help develop assays and give proof of concept data for the use of aptamers in other applications; like protein purification or small molecule-protein diagnostic applications.

By taking advantage of the conformational change in the aptamers upon target binding, the Octet system was implemented for high-throughput screening and characterization of aptamers against small molecule targets (~300Da). The resulting aptamers can, in turn, be used for screening samples for the presence of the target small molecule compound.

This webinar will present data to show the versatility of the BLI platforms with example data from Optimers™ for different aptamer based applications, with a focus on small molecule detection and quantification.

To sign up for rebroadcast click here: REBROADCAST SIGN UP

In Review and News

Arron Tolley winner of CEO Today United Kingdom Award

The award recognises, identifies and honours the most respected companies and their C-level executives operating within the United Kingdom today

Selective antibiotic biosensor for food or environmental monitoring

An aptamer based assay is presented for the determination of the antibiotics oxytetracycline (OTC) and kanamycin (KAN). Magnetic beads were applied for separation, and gold nanoparticles (AuNPs) for signal amplification.

ELISA for Detection of Zika NS1 Protein

Sandwich pair of aptamers but also antbody/aptamer pairs that increased sensitivity by 3 orders of magnitude in buffer and serum.

Coming Soon

Watch for our announcement on therapeutic development with a major pharmaceutical strategic partner and our new catalogue aptamer data sheets
We hope you have enjoyed the October new update- if you would like information on any of the topics we have covered or anything else, please do not hesitate to get in touch or use the form below.

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