Our aptamer combinatorial libraries have approximately one quadrillion (1015) different molecules, giving you unprecedented sequence diversity.
Aptamers are isolated from degenerate combinatorial libraries consisting of approximately 1015 sequences. This huge diversity is derived from a stretch of random nucleotides, typically 20 – 80 nucleotides in length, giving 420 to 480 possible sequence combinations.
An average combinatorial chemical library consists of approximately 100,000 classes of molecules, with the better libraries consisting of approximately 1 million molecules. In contrast, recombinant phage display libraries (such as those used to make HuCAL libraries) have approximately 45 billion different structures. These libraries are ~ 45,000 times bigger than a large combinatorial chemical library.
An aptamer library is 22,000 times bigger than a recombinant phage display library and a billion times bigger than a large combinatorial chemical library.