Cells and Tissues
Cell and Tissue Imaging
Aptamers have significant potential for use as imaging reagents as they can be isolated against cell-lines, tissue samples etc. and can be selected in such a way that they only bind to their intended target and not to related cells (or surrounding tissues).
The ease with which aptamers can be site specifically labelled with a variety of fluorophores also facilitates their use in multiplexed analysis. Aptamers are a great for both epifluorescence and confocal microscopy. Regardless of the light source, aptamers outperform antibodies due to their smaller size, resulting in increased signal intensity and better signal-to-noise ratios. In confocal microscopy, this means ultra-clear visualisation of proteins within tissue sections.