Small Molecule Targeting
Detecting small molecules remains a significant challenge in the life sciences because of a lack of reliable reagents and assays.
Aptamer Group developed an adapted displacement approach that not only improves selection results but also facilitates better assay design and execution.
The binding of our small molecule-targeting aptamers (and Optimers™) relies on a conformational change, which may be exploited in a number of assay formats; including ELISA-like assays, Biosensors, Molecular Beacons and Lateral Flow Devices.
Aptamers selected against small molecules without modifications to target and in assay matrix
Selecting aptamers to small molecule targets is challenging. Immobilising small molecules can change chemical characteristics and sterically hinder aptamer interactions. Aptamer Group use a unique displacement method to address these issues. We select against molecules in solution and in biologically relevant conditions.