5th September, 2017

At Aptamer Group we consider it vital to invest in the scientists of tomorrow. A great method for achieving this is by providing an environment where students can expand their knowledge. By having close ties with the University of York, Aptamer Group is able to support student industrial placements. One student who has been working with us is Banushan Balansethupathy who took an interest in the application of aptamers for the study of proteins. Here is the abstract from a white paper he has written.

ELONA: the evolution of ELISA

Banushan Balansethupathy, Andrew Brentnall

Aptamer Group


The detection and quantification of proteins, peptides and a variety of complex target molecules has become vital in scientific research. One major tool for this is the Enzyme-linked immunosorbent assay (ELISA). This method uses characterised and target specific antibodies to detect and quantify an analyte of interest. A recent method which has evolved from the ELISA method is the Enzyme linked oligonucleotide assay (ELONA), which has similar characteristics in quantifying and detecting an analyte. However, as an alternative to using antibodies, a specific oligonucleotide aptamer is used as the main recognition element in the ELONA. This white paper describes the theory and applications behind these two methods.

If you would like to read the whole paper you can download it here for free.

A diagram showing how ELISA has developed into ELISA

Figure 3 from ELONA: the evolution of ELISA showing how Antibodies and Aptamers can work together

In other news we are pleased to announce that our first webinar series – Aptamers: an alternative or adjunct to antibodies – is beginning this month, on 27th September. This series will take place over 3 webinars on the last Wednesday of the month and registration is free.

If you would like more information you can read about it here:

As always, please contact us, using the form below, if you have any questions regarding the selection of aptamers or to discuss how aptamers can be integrated into your research, discovery or development projects.