Aptamers and their applications in RNAi technology

The RNA interference (RNAi) era, started by Fire and Mello in 1998 completely changed the vision of research involving cell control and therapeutic intervention. RNAi machinery starts from a long dsRNA and pre-microRNA (pre-miRNA) that is cleaved by the ‘Dicer’ enzyme in a short dsRNA fragments called small interfering RNA (siRNA) and miRNA, respectively. This, […]

Aptamers and their applications in immunohistochemistry

Immunohistochemistry has helped to make surgical pathology the ‘gold standard’ for tumour diagnosis. Antibodies have been used extensively as the molecular probes; however, there have been issues with their specificity, which is the most critical determining factor in IHC.

Previous reports have suggested that 40-50 % of diagnostic inconsistencies are related to poor antibody selection, cross […]

Integumen signs MTA with Aptamer Group Ltd

Collaboration to use aptamers in a device to detect SARS-CoV-2 in wastewater
Aptamer Group, developers of Aptamer reagents, is pleased to announce that it has signed a Material Transfer Agreement (“MTA”) with the Integumen. This recently established collaboration is to use  Aptamers in a device to detect SARS-CoV-2 in wastewater. Once ready, the Aptamers will play […]

Aptamer Group and Cytiva form new collaboration for the development of COVID-19 Rapid Test

Collaboration to produce a rapid test for the COVID-19 coronavirus infection
Aptamer Group, is pleased to announce that it has entered into a collaboration with Cytiva, formerly known as GE Healthcare Life Sciences. The company will use its recently developed aptamer reagent combined with Cytiva’s lateral flow technology to produce a Lateral Flow Device (LFD)*. Aptamer […]

Aptamer based strategies for effectively crossing the Blood Brain Barrier

The blood brain barrier (BBB) is a highly specialized network of blood vessels that effectively separates the brain environment from the circulatory system. Delivering drugs into the brain environment has historically been a challenge. This is due to the nature of the BBB anatomy, as it is composed of polarized endothelial cells that are connected […]

Aptamer mediated targeted delivery of cancer therapeutics

The major challenges of cancer research include finding ways to maximize the tolerated dose of chemotherapeutic drug given and balancing this with an acceptable toxicity profile. One promising approach is to transport drugs to their specific target destinations by increasing the selectivity to cancerous cells. This in turn, can shield the drugs from elimination and […]

Aptamer Group making headlines on their Point of Care COVID19 reagent developments

 
Arron Tolley, CEO of Aptamer Group discusses the teams progress on COVID19 tests:
 

https://www.linkedin.com/feed/update/urn:li:activity:6678971478534324225

 

Use of peptide aptamers to generate resistance against plant viruses

Viruses can cause severe infectious symptoms not only in humans and animals but also in plants serving as a threat to the production of agricultural crops. Therefore, prevention of plant virus infections is a major objective in crop protection. There are various traditional strategies for controlling the viral diseases such as crop rotation, pathogen free […]

Real time aptamer-based tracking of circulating therapeutic drugs

The goal of personalized medicine is to precisely tailor treatment to the individual. To this end, the ability to measure drugs in the body rapidly and in real time would hold the promise to revolutionalise healthcare by delivering the right drug, at the right dose, and at the right time. The development of such technologies […]

Aptasensors for rapid and reliable detection of abused drugs

Drug abuse continues to be a growing global concern, causing serious health and economic implications worldwide. These drugs are known to be a strong stimulant to the central nervous system, driving up levels of dopamine, a hormone producing an additive feeling of euphoria.

Overuse or abuse of such drugs has shown to cause many adverse effects […]