Real time aptamer-based tracking of circulating therapeutic drugs

The goal of personalized medicine is to precisely tailor treatment to the individual. To this end, the ability to measure drugs in the body rapidly and in real time would hold the promise to revolutionalise healthcare by delivering the right drug, at the right dose, and at the right time. The development of such technologies […]

Aptasensors for rapid and reliable detection of abused drugs

Drug abuse continues to be a growing global concern, causing serious health and economic implications worldwide. These drugs are known to be a strong stimulant to the central nervous system, driving up levels of dopamine, a hormone producing an additive feeling of euphoria.

Overuse or abuse of such drugs has shown to cause many adverse effects […]

Aptamer based assay for sensitive detection of antibiotics in food and water samples

Antibiotics have been widely used in human medicine, aquaculture and agriculture to treat serious infectious diseases. However, overuse and misuse of antibiotics in some areas have contributed to the residues of antibiotic contaminants in water bodies and food products such as meat and dairy. This misuse has resulted in generation of super bacteria with tolerance […]

Applications of aptamers as GPCR targeting drugs

The current wave of COVID-19 infections around the globe has resulted from a novel coronavirus employing its spike glycoprotein to bind with the protein binding sites of the host cells. These virus particles have the notorious tendency to proteolytically generate mutated biologically active fragments involved in signal transduction pathway resulting in the proliferation and transmission […]

Biomarker detection in serum becomes easier using aptamer based biosensor

30th July

Blood contains a range of protein biomarkers that could be used in the early detection of disease. One important biomarker is human epidermal growth factor receptor 2 (HER2) which is overexpressed in the most common breast cancer. Various HER2 detection techniques have been reported, including FISH or IHC based assays, however, these techniques require […]

Literature Review: Distinguishing glycosylation patterns in proteins for the early detection of cancer.

7th May 2019
Glycosylation is a post-translational modification where a carbohydrate is added to a protein. Glycosylation of proteins serves a number of functions in a cell, including: improve protein folding, forming lipid anchors and cell-to-cell adhesion. While glycosylation of a protein can be vital for its function, any changes in the position or number of […]

The Reusability of Aptamers for Affinity Chromatography

23rd April 2019
We have often shown that aptamers make ideal ‘capture reagents’ for use in target specific affinity chromatography. Their flexible structure makes aptamers ideally suited for the specific binding and controlled release of their target, even in the presence of complex matrixes such as cell lysates or plasma.

During the aptamer selection process, we can […]

Aptamers to discriminate between proteins with Post Translation Modifications

2nd April 2019
Background:

Post Translational Modifications (PTM) are biochemical variations of cetain amino acids made to a protein after biosynthesis. These modifications diversify the proteome and play a fundamental role in regulation and targeting of proteins, their interactions with other molecules, as well as their structure, activity and function. Common types of post-translational modifications include phosphorylation, […]

Fully Optimised Aptamers

Introducing OptimersTM
3rd October 2018
 
Proprietary process with validated improvement in delivery and performance

OptimersTM in 12 weeks
Aptamer Group is pleased to announce availability of  OptimersTM – the new standard for our custom development services.

Aptamer Group is dedicated to continually improve its service offerings to identify the best reagent(s) from within our vast aptamer libraries in the […]

Aptamer Stability

29th August 2018
At Aptamer Group, every custom aptamer project begins with a feasibility study. The target and assay matrix are tested for compatibility and stability with the aptamer library, under a variety of conditions. At this early stage it is important to understand the optimal strategy for the selection, address any potential issues and […]