Rapid small molecules detection using our aptamer-based displacement approach

The challenge
Small molecules such as antibiotics, drugs, toxins and food additives are often perceived as difficult targets to obtain a suitable affinity ligand. The development of rapid, cost-effective, single-step assays for the sensitive and specific detection of small molecules are very attractive for many applications ranging from life sciences to environmental analysis. Unfortunately, current […]

Aptamer based delivery of CRISPR/Cas9 for cancer gene therapy without the need for electroporation

CRISPR/Cas9 therapeutics have been in vitro techniques historically. This review shows the promise of potential in vivo aptamer based delivery of CRISPR/Cas9 therapeutics.

Precise editing of DNA sequences in the human genome can correct mutations or introduce novel genetic functionality, thus providing promising solutions to various diseases. Amongst the various diverse gene editing technology to […]

Aptamers and their applications in immunohistochemistry

Immunohistochemistry has helped to make surgical pathology the ‘gold standard’ for tumour diagnosis. Antibodies have been used extensively as the molecular probes; however, there have been issues with their specificity, which is the most critical determining factor in IHC.

Previous reports have suggested that 40-50 % of diagnostic inconsistencies are related to poor antibody selection, cross […]

Use of peptide aptamers to generate resistance against plant viruses

Viruses can cause severe infectious symptoms not only in humans and animals but also in plants serving as a threat to the production of agricultural crops. Therefore, prevention of plant virus infections is a major objective in crop protection. There are various traditional strategies for controlling the viral diseases such as crop rotation, pathogen free […]

Aptamer based biosensors for rapid and sensitive detection of toxins

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