Rapid small molecules detection using our aptamer-based displacement approach

The challenge
Small molecules such as antibiotics, drugs, toxins and food additives are often perceived as difficult targets to obtain a suitable affinity ligand. The development of rapid, cost-effective, single-step assays for the sensitive and specific detection of small molecules are very attractive for many applications ranging from life sciences to environmental analysis. Unfortunately, current […]

Aptamer based delivery of CRISPR/Cas9 for cancer gene therapy without the need for electroporation

CRISPR/Cas9 therapeutics have been in vitro techniques historically. This review shows the promise of potential in vivo aptamer based delivery of CRISPR/Cas9 therapeutics.

Precise editing of DNA sequences in the human genome can correct mutations or introduce novel genetic functionality, thus providing promising solutions to various diseases. Amongst the various diverse gene editing technology to […]

Aptamers and their applications in RNAi technology

The RNA interference (RNAi) era, started by Fire and Mello in 1998 completely changed the vision of research involving cell control and therapeutic intervention. RNAi machinery starts from a long dsRNA and pre-microRNA (pre-miRNA) that is cleaved by the ‘Dicer’ enzyme in a short dsRNA fragments called small interfering RNA (siRNA) and miRNA, respectively. This, […]

Aptamers and their applications in immunohistochemistry

Immunohistochemistry has helped to make surgical pathology the ‘gold standard’ for tumour diagnosis. Antibodies have been used extensively as the molecular probes; however, there have been issues with their specificity, which is the most critical determining factor in IHC.

Previous reports have suggested that 40-50 % of diagnostic inconsistencies are related to poor antibody selection, cross […]

Aptamer based strategies for effectively crossing the Blood Brain Barrier

The blood brain barrier (BBB) is a highly specialized network of blood vessels that effectively separates the brain environment from the circulatory system. Delivering drugs into the brain environment has historically been a challenge. This is due to the nature of the BBB anatomy, as it is composed of polarized endothelial cells that are connected […]

Aptamer mediated targeted delivery of cancer therapeutics

The major challenges of cancer research include finding ways to maximize the tolerated dose of chemotherapeutic drug given and balancing this with an acceptable toxicity profile. One promising approach is to transport drugs to their specific target destinations by increasing the selectivity to cancerous cells. This in turn, can shield the drugs from elimination and […]

Use of peptide aptamers to generate resistance against plant viruses

Viruses can cause severe infectious symptoms not only in humans and animals but also in plants serving as a threat to the production of agricultural crops. Therefore, prevention of plant virus infections is a major objective in crop protection. There are various traditional strategies for controlling the viral diseases such as crop rotation, pathogen free […]

Real time aptamer-based tracking of circulating therapeutic drugs

The goal of personalized medicine is to precisely tailor treatment to the individual. To this end, the ability to measure drugs in the body rapidly and in real time would hold the promise to revolutionalise healthcare by delivering the right drug, at the right dose, and at the right time. The development of such technologies […]

Aptamer based biosensors for rapid and sensitive detection of toxins

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Applications of aptamers as GPCR targeting drugs

The current wave of COVID-19 infections around the globe has resulted from a novel coronavirus employing its spike glycoprotein to bind with the protein binding sites of the host cells. These virus particles have the notorious tendency to proteolytically generate mutated biologically active fragments involved in signal transduction pathway resulting in the proliferation and transmission […]