Aptamer based strategies for effectively crossing the Blood Brain Barrier

The blood brain barrier (BBB) is a highly specialized network of blood vessels that effectively separates the brain environment from the circulatory system. Delivering drugs into the brain environment has historically been a challenge. This is due to the nature of the BBB anatomy, as it is composed of polarized endothelial cells that are connected […]

Aptamer mediated targeted delivery of cancer therapeutics

The major challenges of cancer research include finding ways to maximize the tolerated dose of chemotherapeutic drug given and balancing this with an acceptable toxicity profile. One promising approach is to transport drugs to their specific target destinations by increasing the selectivity to cancerous cells. This in turn, can shield the drugs from elimination and […]

Use of peptide aptamers to generate resistance against plant viruses

Viruses can cause severe infectious symptoms not only in humans and animals but also in plants serving as a threat to the production of agricultural crops. Therefore, prevention of plant virus infections is a major objective in crop protection. There are various traditional strategies for controlling the viral diseases such as crop rotation, pathogen free […]

Real time aptamer-based tracking of circulating therapeutic drugs

The goal of personalized medicine is to precisely tailor treatment to the individual. To this end, the ability to measure drugs in the body rapidly and in real time would hold the promise to revolutionalise healthcare by delivering the right drug, at the right dose, and at the right time. The development of such technologies […]

Aptamer based biosensors for rapid and sensitive detection of toxins

#aptamers #biosensors #toxins #aptasensors #sensitivedetection #rapiddetection #antibodyalternative #highselectivity #microbialdetection #foodsafety #smallmolecules #aptamergroup #COVID19research #aptamerscience

Applications of aptamers as GPCR targeting drugs

The current wave of COVID-19 infections around the globe has resulted from a novel coronavirus employing its spike glycoprotein to bind with the protein binding sites of the host cells. These virus particles have the notorious tendency to proteolytically generate mutated biologically active fragments involved in signal transduction pathway resulting in the proliferation and transmission […]

Aptamers based ELISA for virus detection – A strong potential in combatting COVID-19 battle

27th April 2020
Currently, viral infection is a serious threat for human beings. The world is facing a global pandemic associated with the COVID-19 virus, for which virulence and infectious dose data are still emerging. With almost 3,025,732 confirmed cases of COVID-19 worldwide and 209,001 deaths as of 27th April 2020 as per WHO, accurate and […]

Aptamers in therapeutic drug monitoring for Cystic Fibrosis

Cystic fibrosis (CF) is one of the most lethal autosomal recessive disorder caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR). It is estimated that about 60–70% of CF patients develop Pseudomonas aeruginosa chronic infection, with progressive loss of lung function, as well as increased antibiotic resistance and mortality.

Tobramycin has become an important […]

Aptamers in prostate cancer in vivo research

Prostate cancer is the most common cancer among men, with approximately 1.1 million new cases diagnosed per year worldwide. Most cancer-related deaths are caused by metastases in vital organs, with bones among the most frequent sites of prostate cancer metastases.

So far, various synthetic carriers have been developed to form compact nano-sized complexes carrying cancer therapeutics […]

Aptamers provide superior staining of cellular receptors under super resolution microscopy

12th December 2019
Continuous improvement in imaging techniques have allowed biologists to explore with accurate methods to label cellular elements as they surpass the limit imposed by the diffraction of light. The resolution is mainly affected by the size of the affinity probes, such as antibodies which are 10-15 nm in size. Moreover, non-specificity, over labeling […]