Cystic fibrosis (CF) is one of the most lethal autosomal recessive disorder caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR). It is estimated that about 60–70% of CF patients develop Pseudomonas aeruginosa chronic infection, with progressive loss of lung function, as well as increased antibiotic resistance and mortality.
Tobramycin has become an important […]
19th December 2019
The contamination of the environment with pesticide residues has become one of the most serious problems of public health in the world, due to their wide application in agriculture industry to guarantee the crop yield and quality. This has necessitated the development of rapid, easy and highly sensitive approaches for the detection of […]
27th August 2019
Malaria is a serious life threatening disease, affecting a large portion of the population in developing countries. Over the last decade, there has been a continuous effort to develop efficient, stable, sensitive and low cost detection system for malaria. Currently, lateral flow based immuno-chromatographic tests are widely used for detection of malaria. However, […]
30th July
Blood contains a range of protein biomarkers that could be used in the early detection of disease. One important biomarker is human epidermal growth factor receptor 2 (HER2) which is overexpressed in the most common breast cancer. Various HER2 detection techniques have been reported, including FISH or IHC based assays, however, these techniques require […]
17th July 2019
Small molecules present an ongoing challenge for antibody production and detection. Development of biosensors for the detection of small molecules is difficult due to the lack of suitable antibodies and the relatively small signals. Tools to detect and quantify them are therefore in high demand.
At Aptamer Group we select aptamers that bind to […]
2nd July 2019
Detecting and quantifying small molecule analytes can be difficult. Our specially designed displacement approach allows us to select aptamers which can directly be used in various biosensor platforms for the detection of small molecules. Binding of the aptamer to the analyte gives a ‘signal amplification’ effect which can be used as a basis for small […]
18th June 2019
Kanamycin is an aminoglycoside antibiotic isolated from Streptomyces kanamyceticus and is widely used to treat various infectious diseases in humans and animals. However, like other aminoglycoside antibiotics, kanamycin exhibits comparatively narrow safety margin as high doses can cause ototoxicity, nephrotoxicity and allergic reactions.
The current methods used for analysis for detecting kanamycin levels in […]
7th May 2019
Glycosylation is a post-translational modification where a carbohydrate is added to a protein. Glycosylation of proteins serves a number of functions in a cell, including: improve protein folding, forming lipid anchors and cell-to-cell adhesion. While glycosylation of a protein can be vital for its function, any changes in the position or number of […]
2nd April 2019
Background:
Post Translational Modifications (PTM) are biochemical variations of cetain amino acids made to a protein after biosynthesis. These modifications diversify the proteome and play a fundamental role in regulation and targeting of proteins, their interactions with other molecules, as well as their structure, activity and function. Common types of post-translational modifications include phosphorylation, […]
9th August 2018
Aptamers continue to demonstrate advantages in platforms and applications which require specific detection of small molecule targets.
There has been a growth in the use of point of care devices across a range of applications and assay types due to a need for rapid and reliable analysis (Vashist 2017). Aptamers are perfectly suited for […]
