Aptamer Applications: Biosensors part 1

4th July

Aptamers are increasingly being used in Biosensors. Biosensors are devices that use biological molecules, especially enzymes or antibodies, or living organisms to detect the presence of an analyte. By modifying an aptamer with an appropriate reporter group, we are able to develop biosensors that measure analytes qualitatively and/or quantitatively.

Modes in which aptamers are utilised […]

Aptamer Applications: ELONA

27th June, 2017
An application that we have proven to be successful for aptamers is Enzyme-Linked Oligonucleotide Assays (ELONA). These are similar to ELISA but utilise the benefits that aptamers offer.

ELONA use aptamers in two ways; to capture the target molecule on the plate and for use as a detection molecule. After the sample is immobilised […]

  • 2 aptamers binding to small molecule targets and one aptamer binding to a large molecule target

What is an aptamer?

10th May 2017
AptaBasics:  ‘What is an Aptamer’?

An aptamer is a sequence of single strand nucleic acid (DNA or RNA) with a variable region of about 40 nucleotide bases. This variable sequence confers each aptamer with a unique 3 dimensional structure and potential ligand binding capability.  These factors make aptamers high affinity and specific binding molecules, […]

  • Small Molecule Binding Aptamer

Selecting Aptamers to Small Molecule Targets

4th May 2017

At Aptamer Group, we employ state-of-the-art methods to select and identify aptamers to small molecule targets. These aptamers can then be modified to achieve goals that are often not possible with other binding molecule technologies.

Challenges with Small Molecule Targets

The accepted approach for the development of antibodies is to prepare small molecule-protein conjugates. However, […]

World AIDS Day

01 December 2016
World AIDS Day is held on the 1st of December of each year and is an opportunity for people worldwide to unite in the fight against HIV. Around 100,000 are currently living with HIV in the UK and an estimated 35 million people suffer from HIV globally.

Ever since AIDS was first recognized in […]

E.coli infections and diagnosis

08 November 2016
Escherichia coli (E. coli) are diverse bacteria, with pathogenic and non-pathogenic strains. The rod-shaped bacterium is a major cause of diarrheal diseases, peritonitis, colitis, urinary tract infections and bacteraemia, costing billions of dollars to treat annually and claiming approximately 2 million lives 1. A BBC News article recently highlighted E. coli as the […]

Novel pneumonia diagnostics

28 October 2016

Streptococcus pneumoniae (S. pneumoniae) is one of the most common bacterial respiratory pathogens worldwide and responsible for a variety of life threatening infectious diseases including pneumonia, meningitis and septicaemia 1. In the developing world, 25% of all preventable deaths in children under five years old are attributed to pneumococcal septicaemia, with over 1.2 […]

Diagnosing MRSA infections

21 October 2016

Staphylococcus aureus (S. aureus) is a gram positive bacterium that can live a double life. Widespread in the environment as a commensal, S. aureus can also be a versatile and dangerous human pathogen. As one of the most commonly isolated pathogens in nosocomial infections S. aureus is adept causing infections in high-risk patients, […]

Aptamers and the Blood-Brain Barrier

26 August 2016

Aptamers have emerged as an exciting and promising new means of treating neurological disease, with the potential to fundamentally change the way we approach CNS-targeted therapeutics. With the propensity to cross the blood–brain barrier (BBB), Aptamers can target specific cell or signalling systems, respond to endogenous stimuli, or act as vehicles for gene […]

Aptamers in Aquaculture

19 August 2016

Aquaculture is the sustainable farming practice of raising aquatic organisms for the purpose of human consumption. Aquaculture has rapidly grown in popularity and is now poised to be a major food source for the global community over the next decade. Common species farmed by aquaculture include fish, crustaceans, molluscs, marine plants and to […]