Spotlight: Laboratory Technician, Katriona Harrison

Working at Aptamer Group:
The continued success of Aptamer Group means that the scientific team continues to grow. One member who joined us this summer is Katriona.  Now she has had the chance to establish herself, we took the opportunity to catch up with her.

Hi Katriona, please tell us a little about yourself.

I am currently a […]

Aptamer Group Update: Quarter 3

Message from the CEO
I am pleased to report that the trends mentioned in the last Newsletter continue to improve. We can now boast successful delivery of aptamers to a range of small and large molecule targets for customers in academia, biotech and big Pharma. We are also moving towards integration of aptamers into devices and […]

  • Comparing healthy to disease state cells using aptamers

Aptamer Application: Biomarker Discovery

22nd August, 2017.
Biomarker Discovery

A biomarker is a measurable indicator showing the presence or severity of a disease state. Using biomarkers to differentiate between healthy and diseased cells can enable the development of specific diagnostics, research tools and targeted therapeutics.

Biomarker Discovery using Aptamers

Traditional biomarker discovery is a long process and relies on multiple comparisons using various […]

  • Aptamer, Flow Cytometry, Data, Stain, Antibody Alternative

Aptamer Application: Flow Cytometry

1st August, 2017.
Flow Cytometry
Flow Cytometry is a technique used to identify biomarkers on cell surfaces and intracellular molecules. Most flow cytometers use fluorescently labelled antibodies to differentiate between cells expressing different markers.

Initially the cell sample is suspended, stained with a fluorescent label and washed to remove any non-specific binding. The suspension is introduced into the […]

Aptamer Applications: Biosensors part 1

4th July

Aptamers are increasingly being used in Biosensors. Biosensors are devices that use biological molecules, especially enzymes or antibodies, or living organisms to detect the presence of an analyte. By modifying an aptamer with an appropriate reporter group, we are able to develop biosensors that measure analytes qualitatively and/or quantitatively.

Modes in which aptamers are utilised […]

  • Library vs log scale of molecules present.

What is an Aptamer Library?

16th May 2017
AptaBasics: What is an Aptamer Library?
Last week we described what aptamers are and the fact they have a variable region. This week we will discuss the scale of the library and why this makes aptamers suitable to many applications.

To generate the largest possible aptamer library, we start with a combinational library of DNA […]