Purification of protein by our highly specific aptamers

4th October 2019
Isolating a single target from a complex sample can be challenging and is often a multi step process which requires increased specificity for the target. Affinity separation is commonly used method as it involves the use of selective binding to purify proteins from a complex sample. Antibodies are commonly used as  capture probes […]

Purification of functional proteins facilitated by aptamer mediated affinity chromatography (AMAC)

19th September 2019
Purification of functional proteins is a key procedure in development and production of biologics and often relies on traditional ion exchange, hydrophobic interaction or size exclusion chromatography. Although these techniques are relatively gentle, obtaining the desired level of purity requires many sequential and sometimes repeated purification steps. Affinity separation is also frequently used […]

The Reusability of Aptamers for Affinity Chromatography

23rd April 2019
We have often shown that aptamers make ideal ‘capture reagents’ for use in target specific affinity chromatography. Their flexible structure makes aptamers ideally suited for the specific binding and controlled release of their target, even in the presence of complex matrixes such as cell lysates or plasma.

During the aptamer selection process, we can […]