Small Molecule IVD

23rd July 2019
Aptamer based ‘gain of signal’ assay for small molecule detection

Detecting small molecules represents a challenge for In vitro diagnostics (IVD) due to sensitivity and specificity limits of many detection methods. Our specially designed displacement approach allows us to select aptamers that can readily be used in various IVD and point of care (POC) […]

Small molecule detection made easier using Fluorescence Anisotropy technique

9th July 2019
Traditionally, immuno-fluorescence polarization-based assays are used to detect small molecules by using antibodies and fluorescently labelled small-molecules. However, the assays do meet limitations such as complex antibody preparation, cost, and most importantly stability. Also the preparation of fluorescently labelled small molecules is challenging. The use of aptamers overcomes the limitations and brings new […]

Small molecules detection with aptamer based BLI and ELISA-like assays

2nd July 2019
Detecting and quantifying small molecule analytes can be difficult. Our specially designed displacement approach allows us to select aptamers which can directly be used in various biosensor platforms for the detection of small molecules. Binding of the aptamer to the analyte gives a ‘signal amplification’ effect which can be used as a basis for small […]