9th July 2019
Traditionally, immuno-fluorescence polarization-based assays are used to detect small molecules by using antibodies and fluorescently labelled small-molecules. However, the assays do meet limitations such as complex antibody preparation, cost, and most importantly stability. Also the preparation of fluorescently labelled small molecules is challenging. The use of aptamers overcomes the limitations and brings new […]
9th July 2019
25th June 2019
Small molecule targets (such as antibiotics, many drugs, toxins, food additives etc) are often perceived as difficult targets to obtain a suitable affinity ligand. They represent a challenge for traditional aptamer selection approaches which rely on immobilisation of the target molecule for efficient partitioning. Modification of the small molecule to facilitate immobilisation often […]
22nd June 2018
Changes in hormone levels can be key indicators to a variety of issues, examples include testosterone levels in general health and well being(1) and diagnosing Cushing’s disease involving the steroid cortisol (2). While these small molecules and others are well documented and their role in health and disease is becoming better understood, researchers […]
Message from the CEO
I am pleased to report that the trends mentioned in the last Newsletter continue to improve. We can now boast successful delivery of aptamers to a range of small and large molecule targets for customers in academia, biotech and big Pharma. We are also moving towards integration of aptamers into devices and […]
19th September, 2017
An insight into working at Aptamer Group
Mateja joined Aptamer Group in August as a Selection Technician. Now she has had the chance to settle in and become established in her role, we took the opportunity to catch up with her.
Can you tell us a bit about your Ph.D.?
I have just finished the research […]
12th September, 2017
Aptamer Applications: Using Aptamers in Lateral Flow Assays
There is a growing need for easy to use, point of care tests. A technology where aptamers can be used to achieve this is in lateral flow assays. A lateral flow assay is a method of detecting the presence (or absence) of an analyte without complicated […]
5th September, 2017
At Aptamer Group we consider it vital to invest in the scientists of tomorrow. A great method for achieving this is by providing an environment where students can expand their knowledge. By having close ties with the University of York, Aptamer Group is able to support student industrial placements. One student who has […]
25th August, 2017
Starting with the end in mind
The use of aptamers in point of care diagnostic devices, for monitoring drug dose levels or for use as therapeutics, requires functionality across a wide variety of conditions.
Aptamer selection starts in conditions optimised to promote aptamer/target interaction to identify the best target-binders. Subsequently, by introducing different pressures, we […]
4th May 2017
At Aptamer Group, we employ state-of-the-art methods to select and identify aptamers to small molecule targets. These aptamers can then be modified to achieve goals that are often not possible with other binding molecule technologies.
Challenges with Small Molecule Targets
The accepted approach for the development of antibodies is to prepare small molecule-protein conjugates. However, […]